A Numerical Approach to the Magnetic Nanoparticle Hyperthermia

Abstract

Magnetic Hyperthermia (MH) is an effective way for cancer treatment and enhancing drug delivery. In this method when magnetic nanoparticles are exposed to the magnetic field, start oscillations which can generate ultrasound waves. These resulting oscillations of nanoparticles may lead to the movement of drug carrier Iiposomes, which can be very useful for an efficient targeting in drug delivery, or produce heat in direct tumor cell killing. In this study, a revolved 3D and a 3D model of fixed and randomly distributed Ferromagnetic nanoparticles were developed. In the 3D model a nanoparticle was assumed in the corner of the hydrogel, while in the 3D model around 100 nanoparticles were randomly distributed in the hydrogel using a Swiss cheese model. A circular homogenous multi-turn coil with a voltage of 10 V was considered as the solenoid. The results of the 3D model showed a maximum magnetic flux density of $0.96 T$ which could induce magnetic forces, while the magnetic force can result in the displacement of the magnetic nanoparticles. The results of the revolved 3D model modified the fact that nanoparticles underwent some displacements. The induced nanoparticle displacements could be due to the generation of ultrasound intracellularly which can enhance the efficiency of drug delivery.