A Qualitative Study to Explore Patient’s experiences on Chemotherapy-induced Nausea and Vomiting: Focusing Impact on Daily Life

Sushil Gour, Anamika Kore, Abhijit Das, J. Dane, R. Maurya
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Abstract

Background: This study aimed to explore the experience of cancer patients about chemotherapy-induced nausea and vomiting and its effect on patients’ daily life. Methods: A descriptive qualitative study was conducted on cancer patients who experience nausea and vomiting due to chemotherapy. Semi-structured interview guide consisting of eight questions was used as a study tool and thematic analysis was done using QDA Miner lite software.Results: Twenty-five participants were included in the final analysis. The median age of the participants was 53 (IQR-15) years and most of the patients were Hindu. All the patients were newly diagnosed. Approximately 80% of patients had received three cycles of chemotherapy by the time of their interviews. Adriamycin, Cyclophosphamide (AC), Docetaxel (T), Paclitaxel and Carboplatin (P+C) were the chemotherapy drugs administered. Our findings suggest that chemotherapy-induced nausea and vomiting has affected many aspects of patient’s lives, especially those related to eating, physical, emotional, and social functioning, but the degree of impact was unique to each patient. Conclusion: The individual experiences of nausea and vomiting during chemotherapy treatment may have a profound effect on treatment compliance and future outcomes. Specific assessment and innovative approaches for its subsequent management are highly needed while considering the complexity of these symptoms.
一项探讨化疗引起的恶心和呕吐患者经历的质性研究:关注对日常生活的影响
背景:本研究旨在探讨癌症患者化疗引起的恶心、呕吐的经历及其对患者日常生活的影响。方法:对化疗后出现恶心呕吐的癌症患者进行描述性定性研究。采用由8个问题组成的半结构化访谈指南作为研究工具,采用QDA Miner lite软件进行专题分析。结果:25名参与者被纳入最终分析。参与者的中位年龄为53岁(IQR-15),大多数患者是印度人。所有患者均为新诊断。在接受采访时,大约80%的患者已经接受了三个周期的化疗。化疗药物为阿霉素、环磷酰胺(AC)、多西紫杉醇(T)、紫杉醇和卡铂(P+C)。我们的研究结果表明,化疗引起的恶心和呕吐影响了患者生活的许多方面,特别是与饮食、身体、情感和社交功能有关的方面,但影响程度对每个患者都是独特的。结论:化疗期间恶心和呕吐的个体经历可能对治疗依从性和未来预后有深远的影响。考虑到这些症状的复杂性,迫切需要对其后续管理进行具体评估和创新方法。
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