M. Heydari, K. Homayouni, M. H. Hashempur, M. Shams
{"title":"THE USE OF TOPICAL CITRULLUS COLOCYNTHIS IN TREATMENT OF PAINFUL DIABETIC NEUROPATHY: A PILOT INTERVENTIONAL STUDY","authors":"M. Heydari, K. Homayouni, M. H. Hashempur, M. Shams","doi":"10.7897/2277-4343.056135","DOIUrl":null,"url":null,"abstract":"Topi cal Citrullus colocynthis formulations are used as botanical treatment for painful diabetic neuropathy in Asian countries . This pilot study aimed to evaluat e the safety and efficacy of topical formulation of Citrullus colocynthis fruit extract in treatment of painful diabetic neuropathy. The study was designed as a prospective interventional case series . Eight adults with clinical diagnosis of painful diabetic neuropathy confirmed by electrodiagnosis received oil - based topical formulation of Citrullus coloc ynthis fruit extract twice daily for three months. The patients were evaluated before and after the intervention in terms of Neuropathic Pain Scale, Electrodiagnostic findings and reported adverse reactio ns after three months. Mean neuropathic pain scores reduced significantly three months after the intervention. Significant small size improvements were documented in some of electrodiagnostic findings. No local or systemic adverse effects were reported. More studies with randomized placebo - controlled design are recommended for meticulous evaluation of the effects of topical Citrullus colocynthis in treatment of painful diabetic neuropathy .","PeriodicalId":171659,"journal":{"name":"International Journal of Research in Ayurveda & Pharmacy","volume":"125 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Ayurveda & Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7897/2277-4343.056135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Topi cal Citrullus colocynthis formulations are used as botanical treatment for painful diabetic neuropathy in Asian countries . This pilot study aimed to evaluat e the safety and efficacy of topical formulation of Citrullus colocynthis fruit extract in treatment of painful diabetic neuropathy. The study was designed as a prospective interventional case series . Eight adults with clinical diagnosis of painful diabetic neuropathy confirmed by electrodiagnosis received oil - based topical formulation of Citrullus coloc ynthis fruit extract twice daily for three months. The patients were evaluated before and after the intervention in terms of Neuropathic Pain Scale, Electrodiagnostic findings and reported adverse reactio ns after three months. Mean neuropathic pain scores reduced significantly three months after the intervention. Significant small size improvements were documented in some of electrodiagnostic findings. No local or systemic adverse effects were reported. More studies with randomized placebo - controlled design are recommended for meticulous evaluation of the effects of topical Citrullus colocynthis in treatment of painful diabetic neuropathy .