THE USE OF TOPICAL CITRULLUS COLOCYNTHIS IN TREATMENT OF PAINFUL DIABETIC NEUROPATHY: A PILOT INTERVENTIONAL STUDY

M. Heydari, K. Homayouni, M. H. Hashempur, M. Shams
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引用次数: 2

Abstract

Topi cal Citrullus colocynthis formulations are used as botanical treatment for painful diabetic neuropathy in Asian countries . This pilot study aimed to evaluat e the safety and efficacy of topical formulation of Citrullus colocynthis fruit extract in treatment of painful diabetic neuropathy. The study was designed as a prospective interventional case series . Eight adults with clinical diagnosis of painful diabetic neuropathy confirmed by electrodiagnosis received oil - based topical formulation of Citrullus coloc ynthis fruit extract twice daily for three months. The patients were evaluated before and after the intervention in terms of Neuropathic Pain Scale, Electrodiagnostic findings and reported adverse reactio ns after three months. Mean neuropathic pain scores reduced significantly three months after the intervention. Significant small size improvements were documented in some of electrodiagnostic findings. No local or systemic adverse effects were reported. More studies with randomized placebo - controlled design are recommended for meticulous evaluation of the effects of topical Citrullus colocynthis in treatment of painful diabetic neuropathy .
外用香瓜多糖治疗疼痛性糖尿病神经病变:一项实验性介入研究
在亚洲国家,枸橼酸盐制剂被用作疼痛性糖尿病神经病变的植物性治疗。本初步研究旨在评价外用西葫芦提取物治疗疼痛性糖尿病神经病变的安全性和有效性。该研究被设计为前瞻性介入病例系列。临床诊断为疼痛性糖尿病神经病变的8例经电诊断证实的成年人接受了以油为基础的柑橘果提取物局部配方,每天两次,持续三个月。对干预前后患者进行神经性疼痛评分、电诊断结果及3个月后不良反应报告。平均神经性疼痛评分在干预后三个月显著降低。在一些电诊断结果中记录了显着的小尺寸改进。没有局部或全身不良反应的报道。建议更多的研究采用随机安慰剂对照设计,以细致地评估外用香瓜多糖治疗疼痛性糖尿病神经病变的效果。
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