Formulation and Evaluation of Methotrexate Nanoparticles by Desolvation Technique

Abstract

Aim: To formulate and evaluate Methotrexate nanoparticles by desolvation technique using intermittent addition method and continuous addition method. Background: Methotrexate (MTX) is an anti-metabolite commonly utilized in chemotherapy and immunosuppressant in auto-immune diseases. Methotrexate is an FDA-accredited folic acid antagonist indicated for the remedy of rheumatoid arthritis due to its excessive potency and efficacy in such patients. The medicinal drug is likewise safe and powerful for sufferers with psoriasis, systemic lupus erythematosus, inflammatory bowel disorder, vasculitis, and many different connective tissue sicknesses. Despite the improvement of various newly focused treatment options, MTX stays the spine of RA remedy because of its robust efficacy and tolerability