Modeling and simulation of a NEUOROBIOFET for application in neurology

Abstract

Acetylcholine sensitive field effect transistor (AchFET) has been modeled and simulated to use as circuit element in a neuron circuit. AchFET has been modeled using enzyme kinetics and site binding theory. Based on the simulated characteristics, it is used as an analog of variable conductance in the Hodgkin-Huxley electrical model of neuron that was used to study the resistance and capacitance properties of a patch of squid axon membrane. PSPICE simulation of the circuit using AchFET gives satisfactory reproduction of sodium and potassium currents and simulated electronic action potential is very similar to the experimentally recorded one. Due to the simplicity of this circuit, it may be used as an ideal unit in neurology to study the receptor function and electrical activity of neuron.