Finite element model for the simulation of laser activated micro- and nano-scale drug delivery systems

Henrique Vilhena, J. Coelho, J. Rebordão
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引用次数: 1

Abstract

This paper describes a flexible model that can be used to simulate laser-based photoactivation of drug delivery systems. It considers Gaussian beams for the excitation while the heat diffusion equation is solved by use of the finite element method. As an example, a typical liposome geometry in the focal volume of a laser beam is simulated and the results are compared with experimental data obtained in the literature, showing a good agreement. The model has potential in the design of drug delivery systems as it can be a starting point for the development of new kinds of micro- and nano-scale drug delivery systems.
激光激活微纳米级给药系统仿真的有限元模型
本文描述了一个灵活的模型,可用于模拟基于激光的药物传递系统的光激活。考虑高斯光束作为激励,热扩散方程采用有限元法求解。作为一个例子,模拟了典型的脂质体在激光束焦点体积中的几何形状,并与文献中得到的实验数据进行了比较,结果显示出很好的一致性。该模型在药物传递系统的设计中具有潜力,因为它可以作为开发新型微纳米级药物传递系统的起点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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