Branch-first continuous perfusion aortic arch replacement. Insight into our results.

Abstract

BACKGROUND Aortic-arch surgery often necessitates interruption of perfusion conferring higher morbidity and mortality compared to other aortic segments. We describe our Branch-first continuous-perfusion aortic-arch replacement (BF-CPAR) technique which overcomes these shortcomings, describing technique, results and improved outcomes. METHODS This represents the senior author's 15-year experience with BF-CPAR. Description of demographics, procedures and outcomes have been stratified by dissection and aneurysm aetiology, with prediction of mortality, cerebro -vascular events, renal failure, and end-organ ischaemia undertaken using multivariable logistic regression analysis. RESULTS From July 2005-February 2021, 155 patients underwent BF-CPAR, 93 for aneurysms and 62 for dissections. Median age at intervention was 66.8 years, 96 (61.9%) male, 18 (11.6%) with history of previous dissection repair, and 49 (31.6%) on an emergent basis. We observed an overall mortality of 4.5% (n=7) and stroke of 3.2% (n=5). Comparing elective to urgent cases, the mortality and stroke rates were significantly lower at 0.0% and 1.9% versus 14.2% and 6.1% (Risk Differences: 14.3% and 2.3%, p<0.01) respectively. Predictors of mortality were age (1.11 per year, 95%CI 1.00-1.23, p=0.05); of stroke were hypercholesterolaemia (14.4, 1.84-111.9, p=0.01) and hypertension (0.07, 0.01-0.84, p<0.01); and of dialysis were dissection (6.60, 1.76-24.7, p<0.01). CONCLUSIONS BF-CPAR is safe and adds to the armamentarium of Aortic Arch Repair. In elective and uncomplicated acute-dissection cases, it has no mortality and low stroke (1.9%), and vital organ dysfunction risk. Its results which are comparable to many of the best currently reported series, is driven by avoidance of cerebral circulatory arrest and reduction of cardiac and visceral ischemic time.