Comparative Bioactivity Study of 45S5 and 58S Bioglasses in Organic and Inorganic Environment

Abstract

Melt derived bioactive glasses and sol-gel derived glasses have been extensively investigated and are reported to be bioactive. Investigation of the bioactivity was conducted in different media, like conventional Simulated Body Fluid (c-SBF), Dulbecco's Modified Eagle's Medium (DMEM) and Tris buffer solution. The aim of this work is to investigate and evaluate thein vitro bioactivity assessment of two commonly used bioactive glasses- 45S5 and 58S-soaked in DMEM and c-SBF, in order to compare the biological response of both glasses in organic and inorganic environ- ments. For the samples immersed in c-SBF, the onset of apatite formation on the surface of 45S5 grains was slightly delayed in comparison to 58S. After 3 days in DMEM 58S powders revealed the formation of a crystalline HCAp phase on the surface of all grains in contrary to 45S5, where a sparsely developed amorphous apatite phase was developed.