The results of treatment of newborns with right-sided and left-sided intrathoracic localization of the liver with diaphragmatic hernia

O. Mokrushina, A. Razumovskiy, E. V. Yudina, I. Afukov, V. Shumikhin, S. Smirnova, E. Zilbert, L. Petrova, N. Erokhina, R. V. Halafov, T.O. Svetlichnaya
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Abstract

BACKGROUND: The right-sided congenital diaphragmatic hernia is the rare pathology. Results of diagnostics, prognosis and treatment usally published as a collection of cases. AIM: Comparition of treatment results of congenital diaphragmatic hernia with the liver as its content in dependancy of the side. MATERIALS AND METHODS: We present a retrospective analysis of 50 newborn patients with congenital diaphragmatic hernia. Patiens were divided in two groups, first with right-sided (19 patients), and second with left-sided hernia (31 patients). Groups were compared by gender and weigth. Comparition criteria was the results of prenatal and postnatal diagnostics, intraoperative data, postoperative period, complications and outcomes. RESULTS: We found predominance of prenatal diagnosis in the second group (48% vs 84%, p = 0,001). The lung-to-head circumference ratio were the same in both groups (0,52 in first, 0,46 in second, p = 0,058). Chance to use thoracoscopic approach in the second group was higer in 5,7 times (48% vs 84%). Postoperative period was easier in the group of right-sided congenital diaphragmatic hernia: artificial ventilation lasted on average 8 days (min 3; max 28) versus 11 (min 4; max 50) days in the first group (p = 0,036). Hospital stay was significantly lower in the second group 18 days (min 12; max 28), versus 50 days in the first group (min 13; max 64), p = 0,011. Recovery chance in patients with right-sided hernia was higher (45% vs 79%, confidence interval 0,0590,814). CONCLUSIONS: Every type of diaphragmatic hernia, including right-sided location, need to be the subgect of research of high compitantive center. Prognostic criteria for right-sided congenital diaphragmatic hernia require furter advanced study, wich is possible only in case of concentration of patients in the same center.
新生儿右、左侧胸内定位肝膈疝的治疗效果
背景:右侧先天性膈疝是一种罕见的疾病。诊断、预后和治疗结果通常作为病例集发表。目的:比较以肝为内容的先天性膈疝侧边依赖性的治疗效果。材料与方法:我们对50例新生儿先天性膈疝患者进行回顾性分析。患者分为两组,一组为右侧疝(19例),二组为左侧疝(31例)。各组按性别和体重进行比较。比较标准为产前和产后诊断结果、术中资料、术后时间、并发症和结局。结果:我们发现产前诊断在第二组中占优势(48% vs 84%, p = 0.001)。两组肺头围比相同(第一组为0.52,第二组为0.46,p = 0.058)。第二组采用胸腔镜入路的几率为5,7次(48%对84%)。右侧先天性膈疝组术后时间较短,人工通气时间平均为8天(最短3天;最大28)vs 11(最小4;第一组最多50天(p = 0.036)。第二组患者住院时间明显缩短18天(最短12天;最长28天),而第一组为50天(最短13天;最大64),p = 0,011。右侧疝患者的康复率更高(45% vs 79%,可信区间0,0590,814)。结论:每一种类型的膈疝,包括右侧位置,都需要成为高竞争中心的研究对象。右侧先天性膈疝的预后标准需要进一步的深入研究,这只有在患者集中在同一中心的情况下才有可能。
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