Neurodegeneración aguda y crónica un continuo en el establecimiento de los desórdenes neurodegenerativos

Abstract

As worldwide human population grows in number and gets older, disabilities derived from neurological disorders become morepresent. In addition to the lack of efforts directed to preventive actions against the occurrence and establishment of a neurologicaldisorder, will lead governmental institutions to face an increasing requirement for treatment and rehabilitations programs to dealwith consequences caused by these disorders. Demonstrating the importance that neuroscientists focus on the design of newparadigms that allow the identification of a potential prophylactic and therapeutic treatment for these disorders, is a key step. In thepresent work, authors did an overall bibliographical review and general description of the mechanisms involved on acute andchronic neurodegenerative damage, trying to show the common points on both kind of damage. Therefore, to identify andsubstantiate the key characteristics that link degenerative progression from an acute damage to the establishment of a chronicalneurological disorder. Highlighting the value of early interventions on acute neurological damage, centered on neuroprotection viacell signaling pathways that could mediate or prevent neuronal damage. Consequently, to spot and notice the repercussions andtranscendence that research in therapeutic strategies focus on mimic and potentiate the compensatory response unchained after aneurological damage, is a key factor to find new treatments for these disorders.