Comparison between Vitamin-D and Urinary Angiotensin Converting Enzyme Levels in Type 2 Diabetic Hypertensive Patients with Non-Diabetic Hypertensive Patients

Abstract

  Objective: To correlate urinary Angiotensin Converting Enzyme–2 (ACE-2) with serum Vitamin D levels in Type 2 Diabetic-Hypertensive and non-Diabetic-Hypertensive patients. Methodology:The Department of Physiology at the University of Health Sciences in Lahore undertook this observational, correlational study from March 2018 to February 2019. The Services Institute of Medical Services (SIMS), Lahore's medical OPD and diabetic centers were used to select 95 hypertension patients between the ages of 30 and 60, divided into 2 groups. Anthropometric parameters, as well as Blood Sugar Random (BSR) and serum Vitamin D were recorded. Urine samples for evaluating angiotensin converting enzyme 2 were collected.Results: Urinary ACE2 showed negative correlation with serum Vitamin D level (r=-0.336, p=0.034) in group A non-diabetic hypertensive patients, but not in group B diabetic hypertensive patients (r=0.07, p=0.677). Despite somewhat greater vitamin D levels in group B, this difference was not statistically significant.Conclusion: There was no link between ACE2 and blood Vitamin D levels in the diabetic hypertensive patients, despite the fact that we hypothesised that vitamin D would be considered as a viable treatment alternative for treating these individuals.