Perspective: Inexorable beta cell deterioration via oxidative stress as a secondary complication of Type 2 Diabetes

Abstract

Received: February 28, 2021; Accepted: March 15, 2021; Published: March 22, 2021 Traditionally, the secondary complications of type 2 diabetes are considered to be caused by chronic hyperglycemia existing over a number of years and involve primarily microvascular disease of eyes, kidneys, and nerves as well as macrovascular disease of large arteries. The cause of progressive hyperglycemia is attributed to the continuing deterioration of pancreatic islet beta cell function. However, this formulation does not directly address why the beta cell continues to deteriorate over the course of the disease.