POTENTIAL OF DUTCH TEAK LEAVES (Guazuma ulmifolia) AS ANTIOXIDANTS AND ANTI-INFLAMMATORIES AGENT

Safira Smaradhna, Zaviera Az Zahra, Carolina Maria Sidabutar, Khaira Eskalatin, Nia Savitri Tamzil, Evi Lusiana, Desi Oktariana, Gita Dwi Prasasty, Nita Parisa
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Abstract

Oxidative stress is an imbalance in the quantity of reactive species and antioxidant activity that is often associated with inflammatory diseases. Inflammation is the main cause of morbidity in most of the world's population. Inflammation occurs when there is an invasion of foreign bodies and pathogenic agents such as bacteria, parasites, and viruses that cause activation of the immune system. The protective effect of the inflammatory process is actually very good under normal circumstances. However, in chronic inflammation, tissue damage becomes uncontrollable and can lead to various diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis and neoplastic transformation. For inflammatory therapy, steroids and non-steroidal drugs (NSAIDs) are usually used, but the use of these drugs can have serious long-term effects. Therefore, the development of anti-inflammatory agents from natural sources such as certain plant species that are safe, efficacious, biocompatible and cost-effective is a rational strategy that can be used to treat inflammatory diseases. One of its species, Guazuma ulmifolia or Dutch teak plant, is widely used in traditional medicine because it contains bioactive compounds, especially proanthocyanidins and flavonoids which have anti-oxidant and anti- microbial properties. The leaves and flowers of Guazuma ulmifolia can be used in fever, gastrointestinal disease, kidney disease and diabetes. Guazuma ulmifolia can protect the gastric mucosa against the harmful effects of NSAIDs through anti-inflammatory and anti-oxidant mechanisms. The extract of Dutch teak leaves (Guazuma ulmifolia) was also effective in reducing the expression of myeloperoxidase in the pulmonary tissue of Wistar white rats with pulmonary contusions .
荷兰柚木叶作为抗氧化剂和抗炎剂的潜力
氧化应激是一种活性物质和抗氧化活性数量的不平衡,通常与炎症性疾病有关。炎症是世界上大多数人发病的主要原因。当有异物和病原体(如细菌、寄生虫和病毒)入侵时,引起免疫系统激活,就会发生炎症。炎症过程的保护作用在正常情况下其实是非常好的。然而,在慢性炎症中,组织损伤变得无法控制,并可导致各种疾病,如类风湿关节炎、多发性硬化症、炎症性肠病、牛皮癣和肿瘤转化。对于炎症治疗,通常使用类固醇和非类固醇药物(NSAIDs),但使用这些药物会产生严重的长期影响。因此,从天然来源如某些植物中开发安全、有效、具有生物相容性和成本效益的抗炎剂是一种可用于治疗炎症性疾病的合理策略。其中的一种,柚木或荷兰柚木,因其含有生物活性化合物,特别是具有抗氧化和抗微生物特性的原花青素和类黄酮而被广泛用于传统医学。枸杞的叶和花可用于发烧、胃肠疾病、肾病和糖尿病。枳实可通过抗炎和抗氧化机制保护胃黏膜免受非甾体抗炎药的有害影响。荷兰柚木叶提取物对肺挫伤Wistar大鼠肺组织中髓过氧化物酶的表达也有降低作用。
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