BIOCHEMICAL PREDICTORS OF EARLY AND LONG-TERM OUTCOMES OF TRAUMATIC BRAIN INJURY IN CHILDREN

Institute of information technology Pub Date : 1900-01-01 DOI:10.47501/978-5-6044060-1-4.24

E. Sorokina, Z. Semenova, V. I. Lukianov, O. Karaseva, S. A. Afanasieva, V. Reutov, L. Roshal, V. Pinelis

引用次数: 1

Abstract

In children with mild and severe traumatic brain injury (TBI), the role of various damage/repair neuromarkers in the outcomes of trauma was studied. It has been shown that in the first days after TBI with adverse outcomes, there was a significant increase in NSE, S100b, NO products and a decrease in the content of BDNF and autoantibodies to NMDA (NR2) glutamate receptors (Glu) in the blood serum. After 6 months with unfavorable outcomes, there was an increase in aAb to S100b and a decrease in BDNF.

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儿童创伤性脑损伤早期和长期预后的生化预测指标

在轻度和重度创伤性脑损伤(TBI)儿童中，研究了各种损伤/修复神经标志物在创伤预后中的作用。研究表明，在出现不良结局的脑外伤后的第一天，血清中NSE、S100b、NO产物显著升高，BDNF和NMDA (NR2)谷氨酸受体(Glu)自身抗体含量下降。结果不佳的6个月后，aAb升高至s1000b, BDNF下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Institute of information technology

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