Brain Tumor (Glioma), Impact Of Immunohistochemistry In Prognosis And Prediction Radiation Oncologist Perspective

Abstract

Primary brain tumors are rare and uncommon tumors comprising only 1.6 percent of cancers, although Metastatic brain tumors are more common entity. Primary CNS neoplasm’s are a challenging group of tumors to treat given their varied patterns of behavior and subsequent varied clinical outcomes. This chapter will focus on the treatment of both adult low-grade gliomas (LGGs) and adult high-grade gliomas (HGGs), with an emphasis on radiation therapy techniques, Signs and symptoms of intracranial tumors depends upon types and histology as well as grade of tumors, Some tumors causes problems by their intracranial extension only for example Glioms, Menangiomas, Pituitary tumors other brain tumors like Primary CNS Lymphomas, Germ cell tumors as well as Primitive Neuroendocrine tumors (PNET ) have strong prediction of leptomeningeal spread, among all primary brain tumor Gioblastoma multiforme (GBM) is the most common primary brain tumor and one of the most lethal in nature due to its infiltrative nature because of this GBM overall survival with surgical resection alone is 3 to 6 month only but if we add adjuvant radiotherapy after surgery its overall survival extends up to 1 year furthermore if we add alkalizing agents chemotherapy its overall survival goes up to 1.5 years.