Comparison between second-look ultrasound and second-look digital breast tomosynthesis in the detection of additional lesions with presurgical CESM.

Abstract

OBJECTIVES To compare second-look US with second-look DBT in the detection of additional lesions (ALs) with presurgical CESM. METHODS We retrospectively included 121 women with 128 ALs from patients who underwent CESM for presurgical staging at our centre from September 2016 to December 2018. These ALs underwent SL-US and a retrospective review of DBT (SL-DBT) performed 1-3 weeks prior to CESM to evaluate the performance of each technique individually and in combination. ALs in CESM images were evaluated according to enhancement type (focus, mass, or non-mass), size (<10 mm or >10 mm) and level of suspicion (BI-RADS 2, 3, four or 5). Our gold standard was post-biopsy histology, post-surgical specimen or >24 month negative follow-up. McNemar's test was used for the statistical analysis. RESULTS Out of the 128 Als, an imaging correlate was found for 71 (55.5 %,) with US, 79 (61.7%) with DBT, 53 (41.4 %) with DBT and US, and 97 (75.8%) with US and/or DBT. SL-DBT demonstrated a higher detection rate vs SL-US in non-mass enhancement (NME) pattern (p:0.0325) and DCIS histological type (p:0.0081). Adding SL-DBT improved the performance vs SL-US alone in the overall sample (p:<0.0001) and in every subcategory identified; adding SL-US to SL-DBT improved the detectability of ALs in the overall sample and in every category except for NME (p:0.0833), foci (p:0.0833) and B3 lesions (p:0.3173). CONCLUSIONS Combined second-look imaging (SL-DBT +SL US) for CESM ALs is superior to SL-DBT alone and SL-US alone. In B3 lesions, NME, and foci, the analysis of a larger sample could determine whether adding SL-US to SL-DBT is necessary or not. ADVANCES IN KNOWLEDGE Thanks to its high sensitivity, CESM is a useful tool in presurgical staging to detect the extent of the disease burden and identify ALs not detected with conventional imaging. Since CESM-guided biopsy systems are still scarcely available in clinical practice, it is necessary to look for other approaches to histologically characterize ALs detected with CESM. In our study, combined second-look imaging (SL-DBT +SL US) showed better performance in terms of detectability of ALs, than either SL-DBT or SL-US alone, and allowed us to identify 91.2% of ALs that turned out to be malignant at final histology; for the remaining 8.8% it was still necessary to perform MRI or MRI-guided biopsy. However, this issue could be solved once CESM-guided biopsies spread in clinical practice. SL-DBT demonstrated a higher detection rate than SL-US in NME and DCIS histology.