Plant-Derived Compounds and Their Potential Role in Drug Development

D. Kaloudas, Robert Penchovsky
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引用次数: 1

Abstract

This article describes how with the development of biotechnology, plants have gained again a prominent place as a relatively inexpensive source for the creation of recombinant pharmaceuticals. Plant-derived compounds have started playing a major role in the pharmaceutical industry with many plant-based products to have found their way in drugs and chemicals used for the treatment of different diseases and their symptoms. Plant-derived compounds have been tested for the treatment of several types of cancer, Central Nervous System disorders, as enhancers during chemotherapy and as vessels for targeted drug delivery. Genetically modified plant cells have been recruited for the production of therapeutic agencies as well as in the creation of expression systems for virus-like particles that could be used as vaccines. Moreover, microRNAs mimicking the plant ones have the ability to inhibit tumors in mammalian cells. This review describes plant-derived compounds and their properties as potential therapeutic agents and precursors for the development of novel drugs in the pharmaceutical industry.
植物源性化合物及其在药物开发中的潜在作用
这篇文章描述了随着生物技术的发展,植物如何再次作为一种相对廉价的重组药物的来源而获得了突出的地位。植物衍生化合物已经开始在制药工业中发挥重要作用,许多植物基产品已经在用于治疗不同疾病及其症状的药物和化学品中找到了自己的方式。植物来源的化合物已经被测试用于治疗几种类型的癌症,中枢神经系统疾病,作为化疗期间的增强剂和靶向药物输送的血管。转基因植物细胞已被用于生产治疗药物,以及用于创建可用于疫苗的病毒样颗粒的表达系统。此外,模仿植物的microrna在哺乳动物细胞中具有抑制肿瘤的能力。本文综述了植物源性化合物及其在制药工业中作为潜在治疗剂和新药开发前体的特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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