Microfluidic circulatory system for the raise of liver urea assay

Abstract

In this research, we propose an in vitro liver circulatory system via the concept of cell pattern technology and microfluidic system. Liver lobule structure in our body consisted of several blood vessel and hepatic tissue. The fluid direction of blood would get in from hepatic portal vein, liver lobule tissue to the hepatic central vein. Hence, in order to mimic the liver circular system in vitro, a connected microchannel system is proposed in this research. This connected system consisted of three parts of channel design, blood vessel chamber, Lobule-flow-mimic channel and liver tissue chamber. Liver circulatory system chip is consisted of blood vessel chamber and liver tissue chamber via dielectrophoresis pattern method and microfluidic channel design.