Prevalence of helicobacter pylori infection in perforated duodenal ulcer in a rural hospital

Abstract

Background : The association of Helicobacter pylori with uncomplicated peptic ulcer disease is well documented. The aim of this study was to observe the prevalence of Helicobacter pylori in duodenal ulcer perforation and to know the sensitivity and specificity ofrapid urease test in detecting Helicobacter pylori on table. Methods : This retrospective observational study was conducted at the department of General Surgery, MOSC Medical college hospital Kolenchery Ernakulum for a period of twelve months from February 2015 to February 2016. A total of fifty cases were included in the study. After stabilization in the Emergency room they were taken up for laparotomy and perforation closure after on table Rapid urease test was done.Specimen from the perforation site was sent for histopathology examination by Giemsa staining. Results: Fifty patients with duodenal perforation were taken up for laparotomy and DU perforation closure was done after on table one-minute rapid urease test. A specimen from the perforation site was sent for pathological examination by Giemsa staining. 35 patients (70%) out of 50 patients were tested positive for Rapid urease test. Of these 35 patients 20 patients (57%) had a previous history of APD and 15 patients presented with duodenal ulcerperforation for the first time. The Sensitivity and specificity of rapid urease test was found to be 100%. Conclusion: The prevalence according to our study of H.pylori in DU perforation is 70% and the Rapid urease test was positive in those cases with a long duration of APD. The sensitivity and specificity of One-minute rapid urease test is almost 100%.