EFFICACY, IMMUNOGENICITY AND SIDE EFFECT OF COVID-19 VACCINE ON PREGNANT AND LACTATING WOMEN: A SYSTEMATIC REVIEW

Anita Sukarno, Mohammad Heri Kurniawan, A. Awaluddin
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引用次数: 2

Abstract

Purpose: To investigate the efficacy, immunogenicity, and side effect of the Covid-19 vaccine on pregnant and lactating women. Methods: We obtained 1366 articles from 7 databases such as PubMed, Google Scholar, ScienceDirect, Cochrane Library, EU Clinical Trials Register, ClinicalTrials.gov, the WHO Clinical Trial Registry. The search terms were “Covid-19 Vaccine”, “Sars-Cov-2 Vaccine”, “Vaccine Efficacy”, “Vaccine Immunogenicity”, “Vaccine Side Effect“, “Pregnant Women”, and “Lactating Women”. Study selection and study quality appraisal were guided by Joanna Briggs Institute (JBI). Results: Fifteen articles were included. Vaccinated pregnant women had a lower risk of Covid-19 infection. Immune responses were detected in maternal blood, cord blood, and breast milk. The T-cell had the potential to against viral variants. Covid-19 vaccination resulted in low disruption among lactating women. There was no difference in side effects between pregnant and nonpregnant women. Conclusions: Covid-19 vaccine lowered infection risk and robust immune responses among pregnant and lactating women.
COVID-19疫苗对孕妇和哺乳期妇女的疗效、免疫原性和副作用的系统评价
目的:探讨新冠肺炎疫苗对孕妇和哺乳期妇女的疗效、免疫原性和毒副作用。方法:从PubMed、Google Scholar、ScienceDirect、Cochrane Library、EU ClinicalTrials Register、ClinicalTrials.gov、WHO ClinicalTrial Registry等7个数据库中获取1366篇文献。搜索词为“Covid-19疫苗”、“Sars-Cov-2疫苗”、“疫苗功效”、“疫苗免疫原性”、“疫苗副作用”、“孕妇”和“哺乳期妇女”。研究选择和研究质量评价由乔安娜布里格斯研究所(JBI)指导。结果:纳入文献15篇。接种疫苗的孕妇感染Covid-19的风险较低。在母体血液、脐带血和母乳中检测到免疫反应。t细胞具有对抗病毒变种的潜力。Covid-19疫苗接种对哺乳期妇女的影响较低。孕妇和非孕妇的副作用没有差别。结论:Covid-19疫苗降低了孕妇和哺乳期妇女的感染风险,并增强了免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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