The Outcomes of Invitro Fertilization and Embryo Transfer in Endometriosis-Associated Infertility: A Case Control Study

Abstract

-The pathophysiology of infertility in endometriosis is still controversial and widely investigated. Several mechanisms are put forward. Whether In Vitro Fertilization-Embryo Transfer (IVF-ET) program in endometriosis is a solution to improve the fertility still needs further studied. Objective : To compare the output of IVF-ET between endometriosis infertility and that of non-endometriosis infertility. Methods : This research is non experimental research with case control design. A retrospective approach with secondary data was conducted in 2017. The samples are fifty endometrial infertility patients and fifty infertility tubal factor and or sperm undergoing IVF-ET program at Permata Hati Clinic, Dr. Sardjito Hospital Yogyakarta. Results : The research output is fertilization rate, i.e. a number of good quality embryo and the success of pregnancy based on pregnancy test. Data analysis was done by statistical test of T test and Chi Square. Multivariate analysis was done by logistic regression. Characteristics of both study groups are similar: in terms of age, BMI, duration of infertility, basal FSH, basal E2, stimulation type and gonadotropin needs. A number of good quality embryos in endometriosis group is lower (2.34 ± 2.33 vs 3.44 ± 2.97; p <0.039), but the fertilization rate is the same (48.58 ± 27.16 vs 55.19 ± 30.9; p > 0.259). Compared to non-endometriosis, endometriosis group has bigger risk of pregnancy failure (OR 3.758; CI95% 1.1112.68; p <0.03). Conclusion : There is no difference in fertilization rates between endometriosis and non-endometriosis. The number of good quality embryo on endometriosis group is lower than non-endometriosis. Pregnancy failure on endometriosis group is higher than non-endometriosis group.