Novel Pharmacotherapeutics for Stress-Related Disorders

Jamie E Mondello, J. E. Pak, D. Lovelock, T. Deak
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Abstract

Most mental health problems associated with psychological distress originate with activation of centrally regulated stress pathways, yet a diverse range of central nervous system and somatic disease states can be influenced by exposure to severe or unrelenting stress. The goal of this chapter is to provide a conceptual framework to guide the development of pharmacological intervention strategies. We propose that careful consideration of the relationship between the timing of stressful life experiences, pharmacological intervention, and the ultimate expression of disease symptomatology is critical for the development of pharmacological interventions to treat stress-related disorders. We review a range of physiological systems that are known to be activated by stress, offering potentially new targets for drug development efforts, and argue that participant selection is a key predictor of drug efficacy trials. In doing so, we point toward inflammatory signaling pathways as a potential final common mediator of multiple stress-related disease states.
压力相关疾病的新药物治疗方法
大多数与心理困扰相关的精神健康问题源于中央调控的应激通路的激活,然而暴露于严重或持续的应激会影响多种中枢神经系统和躯体疾病状态。本章的目的是提供一个概念框架来指导药物干预策略的发展。我们建议仔细考虑压力生活经历的时间、药物干预和疾病症状的最终表现之间的关系,对于开发药物干预来治疗压力相关疾病至关重要。我们回顾了一系列已知被压力激活的生理系统,为药物开发工作提供了潜在的新目标,并认为参与者选择是药物疗效试验的关键预测指标。在此过程中,我们指出炎症信号通路是多种应激相关疾病状态的潜在最终共同介质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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