A low-power implantable neurostimulator for small rodents with functional validation

2019 IEEE Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2019-10-01 DOI:10.1109/BIOCAS.2019.8919215

Jason Wright, J. Wong, Yao-Chuan Chang, Umair Ahmed, S. Zanos, T. Datta

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引用次数: 5

Abstract

Research applications in the field of bioelectronic medicine require miniaturized electronics for neurostimulation featuring high precision, long lifetimes, and small size. Existing devices are often limited by the battery capacity, durability of biocompatible packaging, and/or an experimental setup that restricts subject motion. To improve on these limitations, a neurostimulator for chronic implantation in mice was designed using standard off-the-shelf components and experimentally validated acutely in vivo. The device provides single-channel, constant-current monophasic stimulation with passive charge recovery. Magnetic control enables switching between active and electrical/physiological operational validation states. The quiescent current is 1.4 μA and active current is 160 μA with default stimulation parameters (250 μA amplitude, 32 Hz frequency, 100 μs pulse width), allowing the device to be powered by a single 3V lithium cell for up to 147 days with 2 hours of stimulation per day. The implant was packaged using biocompatible epoxy and preliminary accelerated soak testing results indicate a potential functional lifetime of up to 120 days.

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小型啮齿类动物低功率植入式神经刺激器的功能验证

生物电子医学领域的研究应用需要高精度、长寿命、小尺寸的神经刺激微型化电子器件。现有的设备通常受到电池容量、生物相容性包装的耐用性和/或限制受试者运动的实验设置的限制。为了改善这些局限性，使用标准的现成组件设计了一种用于小鼠慢性植入的神经刺激器，并在体内进行了实验验证。该装置提供单通道、恒流单相刺激和被动电荷恢复。磁控制可以在主动和电/生理操作验证状态之间切换。静态电流为1.4 μA，有源电流为160 μA，采用默认激励参数(250 μA振幅，32 Hz频率，100 μs脉宽)，允许设备由单个3V锂电池供电，每天2小时的激励长达147天。植入物使用生物相容性环氧树脂包装，初步加速浸泡测试结果表明其潜在功能寿命可达120天。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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