Epigenetic: New Insight in Gestational Diabetes Mellitus

Maria Grazia Dalfrà, S. Burlina, Annunziara Lapolla
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Abstract

Gestational diabetes mellitus (GDM) is the more frequent metabolic complication of pregnancy with a prevalence that is significantly increased in the last decade accounting for 12–18% of all pregnancies. Recent evidences strongly suggests that epigenetic profile changes could be involved in the onset of GDM and its related maternal and fetal complications. In particular, the unfavorable intrauterine environment related to hyperglycemia, a feature of GDM, has been evidenced to exert a negative impact on the establishment of the epigenome of the offspring. Furthermore the adverse in utero environment could be one of the mechanisms engaged in the development of adult chronic diseases. The purpose of this article is to review a number of published studies to fill the gap in our understanding of how maternal lifestyle and intrauterine environment influence molecular modifications in the offspring, with an emphasis on epigenetic alterations.
表观遗传学:妊娠期糖尿病的新认识
妊娠期糖尿病(GDM)是妊娠期更常见的代谢并发症,其患病率在过去十年中显著增加,占所有妊娠的12-18%。最近的证据强烈表明,表观遗传谱的改变可能参与GDM的发病及其相关的母胎并发症。特别是与高血糖相关的不利宫内环境,这是GDM的一个特征,已被证明对后代表观基因组的建立产生负面影响。此外,不良的子宫环境可能是参与成人慢性疾病发展的机制之一。本文的目的是回顾一些已发表的研究,以填补我们对母亲生活方式和宫内环境如何影响后代分子修饰的理解空白,重点是表观遗传改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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