Molecular Mechanism and Treatment Progress of Bone Metastasis of Lung Cancer

Abstract

Lung cancer is the most deadly cancer in the world today. Bone metastasis caused by advanced cancer is one of the main causes of cancer pain, which seriously affects the prognosis of patients. More than 50% of patients with non-small cell lung cancer (NSCLC) have bone metastasis during the disease. This transfer site can lead to the development of skeletal related events (SRE), such as severe pain, pathological fracture, spinal compression loss and hypercalcemia, which seriously