The Possible Protective Effect of Galantamine against Paracetamol Induced Hepatic and Renal Toxicity in Rats

Zagazig Veterinary Journal Pub Date : 2022-09-01 DOI:10.21608/zvjz.2022.144673.1183

G. Shams, Shahd Elmesiry

{"title":"The Possible Protective Effect of Galantamine against Paracetamol Induced Hepatic and Renal Toxicity in Rats","authors":"G. Shams, Shahd Elmesiry","doi":"10.21608/zvjz.2022.144673.1183","DOIUrl":null,"url":null,"abstract":"Paracetamol (PCM) is a pain reliever that is also used as an antipyretic and an analgesic after surgery. Overdoses, such as those used in suicide attempts or unintentional mishaps, can produce hepatotoxicity, which can result in rapid liver failure and renal necrosis. Galantamine (GAL) is a reversible and competitive cholinesterase inhibitor that is used to treat Alzheimer's disease and other memory-related diseases. This study aimed to investigate the possible protective role of GAL (0.3 mg/kg P.O) for successive 28 days against PCM (2 g/kg BW P.O) toxicity on day 29 of the experiment. At day 30, blood samples were collected for evaluation of liver function such as serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, albumin/globulin (A/G) ratio and kidney function (urea and creatinine). The obtained results revealed that GAL decreased the levels of ALT, AST, ALP, urea, creatinine and improved the protein profile in comparison with PCM treated group. In conclusion, GAL had a protective effect against PCM toxicity by improving liver and kidney function against hepatic and renal toxicity induced by PCM in rats.","PeriodicalId":137314,"journal":{"name":"Zagazig Veterinary Journal","volume":"186 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zagazig Veterinary Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/zvjz.2022.144673.1183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Paracetamol (PCM) is a pain reliever that is also used as an antipyretic and an analgesic after surgery. Overdoses, such as those used in suicide attempts or unintentional mishaps, can produce hepatotoxicity, which can result in rapid liver failure and renal necrosis. Galantamine (GAL) is a reversible and competitive cholinesterase inhibitor that is used to treat Alzheimer's disease and other memory-related diseases. This study aimed to investigate the possible protective role of GAL (0.3 mg/kg P.O) for successive 28 days against PCM (2 g/kg BW P.O) toxicity on day 29 of the experiment. At day 30, blood samples were collected for evaluation of liver function such as serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, albumin/globulin (A/G) ratio and kidney function (urea and creatinine). The obtained results revealed that GAL decreased the levels of ALT, AST, ALP, urea, creatinine and improved the protein profile in comparison with PCM treated group. In conclusion, GAL had a protective effect against PCM toxicity by improving liver and kidney function against hepatic and renal toxicity induced by PCM in rats.

查看原文本刊更多论文

加兰他敏对扑热息痛所致大鼠肝、肾毒性的可能保护作用

扑热息痛(PCM)是一种止痛药，也用于手术后的退烧药和镇痛药。过量服用，比如在自杀企图或意外事故中使用的药物，会产生肝毒性，导致肝功能迅速衰竭和肾坏死。加兰他明(Galantamine, GAL)是一种可逆的竞争性胆碱酯酶抑制剂，用于治疗阿尔茨海默病和其他记忆相关疾病。本试验旨在探讨连续28 d的GAL (0.3 mg/kg P.O)对试验第29天PCM (2 g/kg BW P.O)毒性的保护作用。第30天采集血液，测定血清碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总蛋白、白蛋白、球蛋白、白蛋白/球蛋白(A/G)比、肾功能(尿素和肌酐)。结果显示，与PCM处理组相比，GAL降低了ALT、AST、ALP、尿素、肌酐水平，改善了蛋白质谱。综上所述，GAL对PCM所致大鼠肝肾毒性具有保护作用，其机制可能是改善大鼠肝肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Zagazig Veterinary Journal

自引率

0.00%

发文量