HIV-Integrase

C. Duda-Seiman, D. Duda-Seiman, M. Putz
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Abstract

HIV Integrase is an enzyme produced by a HIV that enables its genetic material to be integrated into the DNA of the infected cell. IN is a key component in the retroviral pre-integration complex (PIC). All retroviral integrase proteins contain three canonical domains, connected by flexible linkers: an N-terminal HH-CC zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.
HIV-Integrase
HIV整合酶是一种由HIV产生的酶,它能使其遗传物质整合到被感染细胞的DNA中。IN是逆转录病毒整合前复合体(PIC)的关键成分。所有逆转录病毒整合酶蛋白都包含三个典型结构域,由柔性连接体连接:n端HH-CC锌结合结构域,催化核心结构域和c端dna结合结构域。整合发生在病毒RNA/DNA依赖的DNA聚合酶逆转录酶产生双链病毒DNA后。IN的主要功能是将病毒DNA插入宿主染色体DNA,这是HIV复制的关键步骤。整合是细胞的一个不归路,它成为病毒基因组(原病毒)的永久载体。整合是造成逆转录病毒感染持续存在的部分原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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