Application of functional state modelling approach for yeast Sacharomyces cerevisiae fed-batch fermentation modelling

Abstract

Continuous estimation of bioprocess state during yeast fed-batch fermentation requires using accurate mathematical model and parameters that can describe the actual state of the yeast growth during fermentation. Application of functional state modelling approach for the yeast Saccharomyces cerevisiae fed-batch fermentations is presented. The main advantage of the modelling approach over global model with complex structure is that the parameters of each local model can be estimated separately from the other local model parameters. Moreover, this approach makes it easier to perform model simulation and parameter estimation compared with the complex global model. Obtained experimental data from yeast fed-batch fermentations show sufficiently good match with the curves simulated using functional state fermentation model.