Comparative genomic study of Parkinson's disease candidate genes

Abstract

Several candidate genes affect Parkinson's disease in a variety of ways. A comparative analysis is performed using orthologues of these genes in other vertebrate species, such as chimp, mouse, rat, chicken, fugu, and tetraodon. The analysis reveals the presence of transmembrane regions and signal peptides in several sequences of some species, which provides a better understanding of the variability of structural and functional aspects of these genes in different species.