Pesticides Induced Oxidative Stress in Brain and Blood of Female Bandicota bengalensis and Tatera indica

Abstract

Pesicides toxic manifestations have been associated with enhanced generation of reactive oxygen species (ROS) which culminates into oxidative stress (OS). The brain and blood of female Bandicota bengalensis and Tatera indica rats collected from Bathinda region of south west region of Punjab were used to investigate the toxic effects of the environmental contaminants mainly pesticides. Levels of total proteins decreased in all the rats collected from study area. Activity levels of different OS parameters namely catalase (CAT), superoxide dismutase (SOD), glutathione transferase (GST), glutathione reductase (GR) and glutathione peroxidise (GPx) were differentially altered and the product of oxidation namely, malondialdehyde increased significantly (p<0.05) in brain and blood of rats collected from study area as compared to control rats. The results infer that environmental contaminants mainly pesticides leads to number of pathophysiological conditions in brain and for altering antioxidant defence system in rats inhabiting south-west region of Punjab.