ENDOTHELIAL FUNCTION IN PATIENTS WITH COPD AND CARDIOVASCULAR DISEASE (REVIEW)

T. Ashcheulova, N. Gerasimchuk, K. Kompaniiets, O. Honchar
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Abstract

Cardiovascular pathology is one of the frequent comorbidities in patients with chronic obstructive pulmonary disease, due to both genetic predisposition and common risk factors (smoking, senile age, male gender, sedentary lifestyle, obesity). The article shows that development of endothelial dysfunction is one of the earliest phases of pathogenesis in this setting. Endothelial dysfunction mechanisms are defined and characterized, including an imbalance of vasoconstricting and vasodilating agents with the emergence of "vicious circles" that violate hemo-vascular homeostasis. The role of nitric oxide, endothelin-1, intercellular adhesion molecule-1 (ICAM-1) in the development of endothelial dysfunction in COPD patients is discussed. The article defines the concept of oxidative stress, the most potent oxidants and mechanisms of their damaging effect arebeing listed. A particular attention is paid to 8-isoprostane as a golden standard in assessment of oxidative stress in patients with COPD.
慢性阻塞性肺病合并心血管疾病患者的内皮功能(综述)
由于遗传易感性和常见的危险因素(吸烟、老年、男性、久坐不动的生活方式、肥胖),心血管病理是慢性阻塞性肺疾病患者常见的合并症之一。本文表明,内皮功能障碍的发展是这种情况下发病的最早阶段之一。内皮功能障碍的机制被定义和表征,包括血管收缩剂和血管舒张剂的不平衡,以及违反血液血管稳态的“恶性循环”的出现。探讨一氧化氮、内皮素-1、细胞间粘附分子-1 (ICAM-1)在COPD患者内皮功能障碍发展中的作用。本文定义了氧化应激的概念,列举了最有效的氧化剂及其破坏作用的机制。特别关注8-异前列腺素作为COPD患者氧化应激评估的黄金标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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