Male sex as a risk factor for Covid-19 complications

Manuel Rances Angulo-Nizama, Karen Margori Acuña-Centurion, Majumy Jhomira Arribasplata-Gonzales, Andrea Alejandra Aldea-Garcia, Jhoan Gabriel Aspiros-Anticona, Bill Oscar Arana-Yupanqui, Johnny Alexander Aldana-Carrasca, F. Leiva-Cabrera
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Abstract

In different parts of the world, analyses were made on covid-19 positive cases, reaching the conclusion that the percentage of infected men is higher than that of infected women. Cases from 9 years of age to 90 years of age or older were taken into account. Cases studied by covid were taken into account people suffering from other diseases. ACE2 is the angiotensin-converting enzyme 2, which also acts as a receptor for SARS-CoV 2. This enzyme has a positive correlation with estrogen, this hormone increases the release of acids allowing resistance to this virus. Estrogen was also found to help promote the release of immunoglobulin G and immunoglobulin M. Estrogen also helps release nitric oxide which will help suppress virus replication and acts as a vasodilator, which decreases cardiovascular risk. On the other hand, androgens inhibit the release of immunoglobulin G and immunoglobulin M. This male hormone also has the ability to positively regulate the transcription of transmembrane serine protease 2 which induces the fusion of viral and cell membrane, which is why the virus affects men more severely than women.
男性是Covid-19并发症的危险因素
在世界不同地区,对covid-19阳性病例进行了分析,得出的结论是,受感染的男性比例高于受感染的女性。从9岁到90岁或以上的病例被考虑在内。covid研究的病例考虑了患有其他疾病的人。ACE2是血管紧张素转换酶2,也是SARS-CoV 2的受体。这种酶与雌激素正相关,这种激素增加酸的释放从而抵抗这种病毒。雌激素还被发现有助于促进免疫球蛋白G和免疫球蛋白m的释放,雌激素还有助于释放一氧化氮,一氧化氮有助于抑制病毒复制,并起到血管扩张剂的作用,从而降低心血管风险。另一方面,雄激素抑制免疫球蛋白G和免疫球蛋白m的释放,这种雄性激素还具有正向调节诱导病毒与细胞膜融合的跨膜丝氨酸蛋白酶2的转录的能力,这就是为什么病毒对男性的影响比女性更严重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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