Preclinical research of the experimental preparation “Ferosel T”

V. Todoriuk, V. Hunchak, B. Gutyj, D. Gufriy, I. Hariv, R. Khomyk, R. O. Vasiv
{"title":"Preclinical research of the experimental preparation “Ferosel T”","authors":"V. Todoriuk, V. Hunchak, B. Gutyj, D. Gufriy, I. Hariv, R. Khomyk, R. O. Vasiv","doi":"10.32718/UJVAS1-1.01","DOIUrl":null,"url":null,"abstract":"The results of preclinical studies of the new ferrodextran preparation “Ferosel T”, which contains ferrum and selenium, are presented. It has been established that at oral administration of ferrocellus T in a prophylactic dose of 2 ml/kg b.w. and the therapeutic dose of 4 ml/kg for 3 days in a row in the stomach of laboratory rats did not show toxic effects. No toxic effect of T ferrocellus is established at introducing it into the stomach in doses in 3 and 10 times higher than the therapeutic ones. Under conditions of subcutaneous administration of the drug, the death of white rats was not observed, only short-term inhibition of laboratory animals, which was prescribed the drug in a dose of 10 ml/kg b.w. It was established that in the preventive and optimal therapeutic doses the drug did not affect the detoxification function of the liver. In rats, which ferrocellus T was administered at maximum therapeutic and possibly toxic doses, the duration of hexenal sleep was for 32 and 35% higher relative to control values. The investigation of the emotional and behavioral reactions of laboratory animals after administration of ferrocellus T for 21 days in therapeutic and maximum therapeutic doses did not show a significant effect on the nervous system. In terms of hyperemia and swelling of the skin and the thickness of the skin, ferrocellus T in prophylactic and therapeutic doses upon application to rabbit skin did not cause local irritation. Separate injection of the drug “Ferosel T” by sub-planar way to guinea pigs in 0.1 ml. did not cause swollen reactions of the paws. As a result of the conducted research, no allergenic properties of the drug “Ferosel T” were found. In laboratory rats, which were introduced ferrosel T in the prophylactic dose of probable changes in the weight of the heart, liver, spleen and kidneys is not established. In rats, which were administered ferrocellus T in an optimal therapeutic dose, in comparison with control weights of the spleen and liver, respectively, was in 10.3 and 6.4% higher. When introducing ferrocellus T at the maximum therapeutic dose, the mass of the spleen and liver was in 14.0 and 15.0% higher, respectively. The results of the studies indicate that the drug “Ferosel T” is safe when used for the prevention and treatment of animals.","PeriodicalId":231752,"journal":{"name":"Ukrainian Journal of Veterinary and Agricultural Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"36","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukrainian Journal of Veterinary and Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32718/UJVAS1-1.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 36

Abstract

The results of preclinical studies of the new ferrodextran preparation “Ferosel T”, which contains ferrum and selenium, are presented. It has been established that at oral administration of ferrocellus T in a prophylactic dose of 2 ml/kg b.w. and the therapeutic dose of 4 ml/kg for 3 days in a row in the stomach of laboratory rats did not show toxic effects. No toxic effect of T ferrocellus is established at introducing it into the stomach in doses in 3 and 10 times higher than the therapeutic ones. Under conditions of subcutaneous administration of the drug, the death of white rats was not observed, only short-term inhibition of laboratory animals, which was prescribed the drug in a dose of 10 ml/kg b.w. It was established that in the preventive and optimal therapeutic doses the drug did not affect the detoxification function of the liver. In rats, which ferrocellus T was administered at maximum therapeutic and possibly toxic doses, the duration of hexenal sleep was for 32 and 35% higher relative to control values. The investigation of the emotional and behavioral reactions of laboratory animals after administration of ferrocellus T for 21 days in therapeutic and maximum therapeutic doses did not show a significant effect on the nervous system. In terms of hyperemia and swelling of the skin and the thickness of the skin, ferrocellus T in prophylactic and therapeutic doses upon application to rabbit skin did not cause local irritation. Separate injection of the drug “Ferosel T” by sub-planar way to guinea pigs in 0.1 ml. did not cause swollen reactions of the paws. As a result of the conducted research, no allergenic properties of the drug “Ferosel T” were found. In laboratory rats, which were introduced ferrosel T in the prophylactic dose of probable changes in the weight of the heart, liver, spleen and kidneys is not established. In rats, which were administered ferrocellus T in an optimal therapeutic dose, in comparison with control weights of the spleen and liver, respectively, was in 10.3 and 6.4% higher. When introducing ferrocellus T at the maximum therapeutic dose, the mass of the spleen and liver was in 14.0 and 15.0% higher, respectively. The results of the studies indicate that the drug “Ferosel T” is safe when used for the prevention and treatment of animals.
实验制剂“费罗赛尔T”的临床前研究
本文介绍了新型右旋铁糖酐制剂“Ferosel T”的临床前研究结果,该制剂含有铁和硒。实验大鼠胃中以预防剂量2ml /kg体重和治疗剂量4ml /kg连续3天口服铁胞菌T无毒性作用。将铁胞T以高于治疗剂量3倍和10倍的剂量引入胃中,没有确定其毒性作用。在皮下给药条件下,未观察到大鼠的死亡,仅对实验动物有短期抑制作用,给药剂量为10 ml/kg b.w。在预防和最佳治疗剂量下,该药物不影响肝脏的解毒功能。在大鼠中,以最大治疗剂量和可能的毒性剂量给予铁细胞T,其己烯醛睡眠时间相对于控制值高出32%和35%。实验动物在给予T铁细胞治疗剂量和最大治疗剂量21天后的情绪和行为反应调查未显示对神经系统有显著影响。在皮肤充血肿胀和皮肤厚度方面,预防剂量和治疗剂量的铁细胞T在兔皮肤上应用后均未引起局部刺激。经亚平面法给豚鼠单独注射药物“Ferosel T”0.1 ml,未引起脚掌肿胀反应。在进行的研究中,没有发现药物“Ferosel T”的过敏特性。在实验大鼠中,对其引入铁塞尔T的预防剂量对心、肝、脾和肾的体重可能产生的变化尚未确定。在大鼠中,以最佳治疗剂量给予铁细胞T,与对照组相比,脾脏和肝脏的重量分别高出10.3和6.4%。当以最大治疗剂量引入铁细胞T时,脾脏和肝脏的质量分别增加14.0%和15.0%。研究结果表明,药物“Ferosel T”用于预防和治疗动物是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信