Effects of glucose in blood and skin impedance spectroscopy

AFRICON 2007 Pub Date : 2007-12-12 DOI:10.1109/AFRCON.2007.4401489

C.E.F. Amaral, B. Wolf

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引用次数: 19

Abstract

Painless control of blood glycemic levels could improve life quality of diabetes patients, enabling a better regulation of hyper- and hypoglycaemia episodes and thereby avoiding physiological complications. The aim of this work is to investigate complex impedance detection of glucose levels in aqueous solutions, blood samples and non-invasive assays. Besides the results of such topology, baseline correction is also presented as an alternative to improve the system performance. First, D-glucose is analyzed with interdigital electrodes in aqueous solutions, showing correlations higher than 0.9 for phase and resistance components, both between 150 kHz and 650 kHz. Blood samples also confirm the importance of complex measurements in similar frequencies, with angle correlating 0.7 with glucose (150 kHz). Finally, skin impedance is obtained with tetrapolar electrodes, resulting in a maximal correlation of 0.62 for the same parameter and range as in blood. Analysis of the transcutaneous prediction with time indicates that the noninvasive precision of 16.47 mg/dL may reflect trends in arterial glucose changes faster than standard methods, appealing for the monitoring of all complex components of impedance.

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葡萄糖对血液和皮肤阻抗谱的影响

无痛控制血糖水平可以改善糖尿病患者的生活质量，更好地调节高血糖和低血糖发作，从而避免生理性并发症。这项工作的目的是研究复杂的阻抗检测葡萄糖水平在水溶液，血液样本和非侵入性分析。除了这种拓扑的结果，基线校正也提出了一种替代方案，以提高系统性能。首先，用指间电极在水溶液中分析d -葡萄糖，在150 kHz和650 kHz之间，相位和电阻分量的相关性高于0.9。血液样本也证实了相似频率下复杂测量的重要性，与葡萄糖(150 kHz)的角度相关为0.7。最后，用四极电极获得皮肤阻抗，在与血液相同的参数和范围内，最大相关系数为0.62。经皮预测的时间分析表明，16.47 mg/dL的无创精度可以比标准方法更快地反映动脉葡萄糖变化的趋势，呼吁监测所有复杂的阻抗成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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AFRICON 2007

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