Analysis of Influencing Factors of Diabetic Foot Minor Amputation

Abstract

Objective: To investigate the factors that influence diabetic foot (DF) minor amputation. Methods: In this case-control study, the clinical data of 955 hospitalized patients with DF were retrospectively analyzed, according to whether hospitalization amputation was divided into minor amputation and the non-amputation group, compared two groups of general data, laboratory examination, diabetes complications and complications, such as differences, multiple factors regression analysis DF Risk factors associated with minor amputation in patients. Results: There were statistically significant differences between the two groups in DPN, DR, PAD, ABI, TBI, and Wagner grades, as well as age, sex, HbA1c, FPG, Scr, SUA, TC, ALB, HDL-C, WBC, and Hb (P<0.05). The logistic regression analysis that HbA1c (odds ratio [OR] 1.082 [95% CI 1.011–1.158], p= 0.023), ABI＜0.9 (odds ratio [OR] 1.793 [95% CI 1.316–2.443], p=0.000), TBI＜0.7(odds ratio [OR] 2.569 [95% CI 1.889–3.495], p=0.000), Wagner classification (odds ratio [OR] 2.792 [95% CI 2.303–3.384], p=0.000) and PAD (odds ratio [OR] 2.343 [95% CI 1.731–3.170], p=0.000) were significant risk factors for DF minor amputation (P＜0.05). Higher Hb (odds ratio [OR] 0.981 [95% CI 0.973–0.988], p=0.000) was an independent protective factor for minor amputation. Conclusion: HbA1c, lower ankle brachial index level, and lower toe-brachial index level were all related with minor amputation. Wagner classification and diabetic peripheral angiopathy may represent a novel independent factor. In light of these concerns, early preventive and timely multidisciplinary assistance is critical to prevent diabetic foot minor amputation.