Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats

International Journal of Homeopathy & Natural Medicines Pub Date : 2019-05-20 DOI:10.11648/J.IJHNM.20190501.14

M. El-Sayed, S. Awad, M. Yousef, A. Wahba, A. Attar, M. Zedan

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引用次数: 1

Abstract

Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly ( P P P <0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.

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乳蛋白水解物对2型糖尿病大鼠血液学指标的影响

牛奶蛋白衍生的生物活性肽可用于新生儿和成人的人类营养，因为它们被声称是改善健康的成分，可用于降低疾病风险或增强某些生理功能。本研究探讨了口服乳蛋白浓缩物(MPC)和乳蛋白浓缩物水解物(MPCH)对四氧嘧啶诱导的糖尿病大鼠体重、器官相对重量和血液学参数的影响。这些动物在糖尿病稳定一周后被分成六组。糖尿病组和非糖尿病组分别给予胃内剂量的MPC或MPCH (150mg/kg B.W)，持续6周。MPC和MPCH饲料处理显著(P P P <0.05)降低了糖尿病和非糖尿病大鼠的单核细胞，而口服MPC对糖尿病和非糖尿病大鼠的单核细胞无影响。MPC和MPCH降低了T2D对大鼠体重、脏器重量的有害影响，改善了正常大鼠和糖尿病大鼠的大部分血液学指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Homeopathy & Natural Medicines

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