Evaluation of humoral response of individuals naturally exposed to malaria against synthetic and recombinant antigens representing Plasmodium vivax TRAP protein

Abstract

Introduction: Thrombospondin-related adhesive protein (TRAP) of malaria parasites is essential for sporozoite motility and invasions into mosquito’s salivary gland and vertebrate’s hepatocyte. Due this importance, it is a promising target for pre-erythrocytic vaccine. Despite few reports on naturally acquired immune response against Plasmodium vivax TRAP (PvTRAP) are available, the results are conflicting and poorly explored in the Amazon region.