Biomarkers for Alzheimer’s disease

A. Vergallo, H. Hampel, R. Bun, S. Lista
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Abstract

Reflecting the neuropathological hallmarks of Alzheimer’s disease (AD), cerebrospinal fluid (CSF) concentrations of Aβ‎1-42, t-tau, and p-tau and positive amyloid positron emission tomography (PET) imaging are considered core biomarkers for AD. Unfortunately, their use for screening is limited by their invasive nature (CSF biomarkers) or high cost (PET imaging). Among the biologic specimens that may be scrutinized for identifying novel AD biomarkers, circulating blood is a convenient source for sampling. The dynamic range of high-throughput technological platforms, coupled with advances in bioinformatics, holds the promise that proteomics will be a significant contributor to the field of blood-based AD biomarkers. Here, the chapter summarizes the blood-based biomarker platforms applied to the investigation of AD and reviews recent achievements in plasma/serum proteomics related to AD. These findings set the stage for the implementation of systems biology in the context of the evolving precision medicine paradigm for AD.
阿尔茨海默病的生物标志物
反映阿尔茨海默病(AD)的神经病理学特征,脑脊液(CSF)中Aβ 1-42、t-tau和p-tau的浓度以及正淀粉样正电子发射断层扫描(PET)成像被认为是AD的核心生物标志物。不幸的是,由于其侵入性(脑脊液生物标志物)或高成本(PET成像),它们在筛查中的应用受到限制。在可用于鉴定新型AD生物标志物的生物标本中,循环血液是一种方便的采样来源。高通量技术平台的动态范围,加上生物信息学的进步,使蛋白质组学有望成为基于血液的AD生物标志物领域的重要贡献者。在这里,本章总结了用于阿尔茨海默病研究的基于血液的生物标志物平台,并回顾了与阿尔茨海默病相关的血浆/血清蛋白质组学的最新进展。这些发现为在阿尔茨海默病不断发展的精准医学范式背景下实施系统生物学奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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