GLC determination of paracetamol and d-propoxyphene.

W J Serfontein, L S de Villiere, L S Villiers, D Botha
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Abstract

d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.

对乙酰氨基酚和d-丙氧酚的GLC测定。
利用药物微相萃取得到的提取物,采用GLC法测定大鼠血浆、大鼠脑匀浆和人血浆中d-丙氧苯和d-去甲丙氧苯的含量。以咖啡因为内标,对乙酰氨基酚的邻丁酸酯衍生物进行GLC分离。本文讨论了生物材料中d-丙氧基和d-去甲丙氧基的GLC测定中存在的问题,并着重介绍了微相萃取法定量测定这些药物的优点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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