Validity and feasibility of the self-report EQ-5D-Y as a generic Health-Related Quality of Life outcome measure in children and adolescents with Juvenile Idiopathic Arthritis in Western Cape, South Africa

Des Scott, C. Scott, J. Jelsma, D. Abraham, J. Verstraete
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引用次数: 10

Abstract

Background Health-Related Quality of Life (HRQoL) data together with clinical findings allow for monitoring of intervention efficacy and the effect on HRQoL. Children with Juvenile Idiopathic Arthritis (JIA) experience symptoms often persisting into adulthood, emphasising the need to track HRQoL. Objectives The aim of this study was to investigate psychometric properties of the EuroQol five-dimensional youth questionnaire (EQ-5D-Y) in children with JIA. Methods A cross-sectional, analytical study design was used. Children 8 to 15 years were recruited, completing the self-report EQ-5D-Y and two other HRQoL questionnaires. Known group validity was established by comparing the effect size between children with different disease severities. Concurrent validity was tested using Kruskal–Wallis to compare the ranking of scores on different questionnaires. Feasibility was assessed by number of missing responses and time to complete each questionnaire. Results All questionnaires were able to distinguish between children with different JIA severity. There was a significant difference in ranking of most Juvenile Arthritis Multidimensional Assessment Report dimension scores across EQ-5D-Y levels, (p < 0.05), indicating concurrent validity. There was poor concurrent validity with the PedsQL dimensions tested with EQ-5D-Y, except for ‘pain’ (p = 0.001). The EQ-5D-Y was the quickest to complete with no missing values. Conclusion This study showed that the EQ-5D-Y is valid and feasible in measuring HRQoL in JIA children and adequately responsive to detect change over time. Clinical implications It is quick and easy to use in a busy clinical setting, allowing for effective JIA management monitoring.
自我报告EQ-5D-Y作为南非西开普省青少年特发性关节炎儿童和青少年健康相关生活质量的通用结局指标的有效性和可行性
背景:与健康相关的生活质量(HRQoL)数据和临床结果可以监测干预效果和对HRQoL的影响。患有幼年特发性关节炎(JIA)的儿童的症状通常持续到成年,这强调了跟踪HRQoL的必要性。目的本研究的目的是探讨EuroQol五维青少年问卷(EQ-5D-Y)在JIA儿童中的心理测量特征。方法采用横断面分析研究设计。招募8 - 15岁的儿童,完成EQ-5D-Y自述和另外两份HRQoL问卷。通过比较不同疾病严重程度患儿间的效应量,建立已知的组效度。同时效度测试采用Kruskal-Wallis比较不同问卷的得分排序。通过缺失回答的数量和完成每份问卷的时间来评估可行性。结果所有问卷均能区分不同JIA严重程度的患儿。多数《少年关节炎多维评估报告》维度得分在EQ-5D-Y水平上的排名差异有统计学意义(p < 0.05),表明存在并发效度。除“疼痛”外,EQ-5D-Y测试的PedsQL维度的并发效度较差(p = 0.001)。EQ-5D-Y是最快完成没有缺失值。结论本研究表明EQ-5D-Y在JIA患儿HRQoL测量中是有效和可行的,并能充分反映其随时间的变化。临床意义在繁忙的临床环境中使用快速方便,允许有效的JIA管理监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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