Co-Pathogenesis of Human Herpesvirus with HIV In Africa

P. Waliaula
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Abstract

Human Herpesviruses (HHV’s) are ubiquitous in human populations globally, and they cause significant morbidity and mortality. HHV’s establish a latent infection that is accompanied by periodic virus reactivation as a result of HIV infections. Further, HIV/AIDS infection in sub-Saharan Africa is perceived to be a significant health concern as it accounts for up to 70% of infectious diseases in the region. Until now, the role played by HHVs is increasingly being recognized. The co-infection of HIV with HHV’s changes severity or the natural course of HIV infection which defines the AIDS conditions in HIV infected individuals. Presently, treatment of HIV/AIDS by antiviral drugs targets the clinical manifestations of both HIV and HHVs at their productive stage and boost the immunity of HIV infected individuals, but they are ineffective at eliminating these viruses (HHVs and HIV) from the infected persons. This review focuses on outlining the epidemiology, distribution and role played by HHV’s in the pathogenesis of HIV infection in African countries. Additionally, this information is significant in crystallizing and providing an update on recent advancements on HHV’s and HIV infections in Africa and possible future directions in this field of research.
非洲人类疱疹病毒与艾滋病毒的共同发病机制
人类疱疹病毒(HHV’s)在全球人群中普遍存在,并导致显著的发病率和死亡率。HHV建立了一种潜伏感染,伴随着周期性的病毒再激活,这是HIV感染的结果。此外,艾滋病毒/艾滋病感染在撒哈拉以南非洲被认为是一个重大的健康问题,因为它占该区域传染病的70%。直到现在,hhv的作用越来越被认识到。HIV与HHV变化的严重程度或HIV感染的自然过程的共同感染,定义了HIV感染者的艾滋病状况。目前,抗病毒药物治疗HIV/AIDS针对的是HIV和hhv在其产生阶段的临床表现,并能提高HIV感染者的免疫力,但不能有效地将这些病毒(hhv和HIV)从感染者体内清除。本文综述了非洲国家HIV感染的流行病学、分布及其在发病机制中的作用。此外,这一信息在明确和提供关于非洲艾滋病毒和艾滋病毒感染的最新进展以及这一研究领域可能的未来方向方面具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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