SYNTHESIS OF 8-BROMOADENOSINE AT DIFFERENT PH VALUES

Abstract

This article shows methods for the preparation of 8-bromoadenosine which is an important intermediate in the syntheses of analogs of purines nucleosides and nucleotides with a broad spectrum of biological activity. The influence of the pH values of the medium on the yield of 8-bromoadenosine was studied. It was showed that pH 4.3 is optimal for the preparation of 8-bromoadenosine by reaction of adenosine with a solution of bromine in water.