The current state of chemotherapy for the treatment of gastrointestinal stromal tumors with different genotypes: a narrative review

Yingying Xu, Wenqing Hu, K. Xiao, Feng Wang, W. Guan, L. Zong
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Abstract

Abstract Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the digestive system and are not sensitive to traditional chemotherapy. Therefore, historically, surgical resection was the only effective therapy. However, the emergence of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of GISTs, because they target c-Kit and PDGF receptor-a (PDGFRA), which are important in GIST development and progression. As research into c-Kit and PDGFRA continues, an increasing number of different TKIs are being used in the clinical setting. This review aims to discuss the current state of chemotherapy for the treatment of GISTs with different genotypes.
不同基因型胃肠道间质瘤的化疗现状:叙述性回顾
胃肠道间质瘤(gist)是最常见的消化系统间质肿瘤,对传统化疗不敏感。因此,从历史上看,手术切除是唯一有效的治疗方法。然而,酪氨酸激酶抑制剂(TKIs)的出现已经彻底改变了GIST的治疗,因为它们靶向c-Kit和PDGF受体-a (PDGFRA),这在GIST的发生和发展中是重要的。随着对c-Kit和PDGFRA研究的继续,越来越多不同的tki被用于临床环境。本文就不同基因型间质瘤的化疗治疗现状进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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