Stability of MRI Radiomic Features of the Hippocampus: An Integrated Analysis of Test-Retest Variability

Abstract

Radiomic is a quantitative method to extract medical features and it can extend details that are invisible to human eyes. Studies have suggested that the radiomics of the hippocampus is a potential imaging biomarker for several diseases, including Alzheimer disease, mild cognitive impairment and multiple sclerosis. The main aim of the present study is to investigate the test-retest reproducibility of the radiomics measures of the hippocampus. For this purpose, the intra-class correlation coefficient (ICC) and overall concordance correlation coefficient (OCCC) of the radiomics properties of the hippocampus were well studied in a dataset including 19 subjects who were scanned two times. The result highlights that most of the hippocampal texture are repeatable, and the possibility that texture may serve as a neuroimaging biomarker for the clinical study.