The Role of the Laboratory Service in the Timely Assessment Of Risk Factors in Patients with Thyroid Nodules as a Tool to Prevent Postoperative Complications

Abstract

Aim: To study of thyroid hormones with one-time determination of risk factors in the laboratory. Material and methods: The examination included the following researches: questionnaire, ultrasound examination with fine-needle aspiration (FNA), cytological examination, determination of the concentration of thyroid hormones and determining the body mass index. Results and conclusions: the size and area of the tumor according to ultrasound (H = 2.30, p> 0.05 and H = 1.92, p> 0.05, respectively). At the same time, patients of the 1st group were younger in age than (when) compared with patients of other groups. For benign thyroid tumors (group I) are characterized by the following data: the level of free thyroxine (FT4) in the serum of 66.7% of patients did not exceed normal and averaged 14.0 (8.0-16.29) pmol/l. Group with suspected tumor malignancy include: very low concentration of FT4 in serum (1.94 (1.44-7.00) pmol/l); high level of FT3 production in 40.0% of cases with a shift of the mean values to the upper limit of the reference interval. Thyroid status of patients with malignant thyroid tumors (group III) is characterized by elevated levels of TSH compared with benign tumors (p <0.05) and suspected malignancy of the tumor (p <0.1). A significant decrease in the production of FT4 in the serum (7.4 times compared with the benign course; p <0.001) against the background of average regulatory levels of FT3.