Association between Lipid Profiles and Renal Functions among Adults with Type 2 Diabetes

International Journal of Diabetes and Metabolism Pub Date : 2019-07-24 DOI:10.1159/000502005

S. Hamzah

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引用次数: 1

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) affects renal functions and lipid profiles of patients. Objectives: In this study, 100 patients (65 females, 35 males) with T2DM were evaluated to determine whether renal function characteristics and lipid profiles are associated with T2DM. Methods: Blood samples were collected from all patients with T2DM, and the levels of hemoglobin A1c (HbA1c), blood urea, serum creatinine, cholesterol, triglyceride (TGR), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL) were analyzed. Results: A direct correlation of blood sugar and HbA1c was observed with blood urea, serum creatinine, serum cholesterol, serum TGR, HDL, LDL, and VLDL. The results revealed elevated TGR levels in patients administered medications for hyperglycemia. Furthermore, serum TGR levels were significantly correlated with blood sugar levels (p = 0.035). Blood urea levels were significantly correlated with glycated hemoglobin (p = 0.008). Blood urea, serum creatinine, and serum cholesterol levels were highly significantly correlated with HbA1c (p = 0.008, 0.017, and 0.005, respectively), while HDL, LDL, and VLDL were not significantly correlated with HbA1c. Conclusion: This study highlights the importance of serum TGR and serum creatinine measurement for guiding the treatment of T2DM.

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成人2型糖尿病患者血脂与肾功能的关系

2型糖尿病(T2DM)影响患者的肾功能和血脂。目的:本研究对100例T2DM患者(女性65例，男性35例)进行了评估，以确定肾功能特征和血脂是否与T2DM相关。方法:采集所有T2DM患者的血样，分析其血红蛋白A1c (HbA1c)、尿素、血清肌酐、胆固醇、甘油三酯(TGR)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、极低密度脂蛋白(VLDL)水平。结果:血糖和HbA1c与血清尿素、血清肌酐、血清胆固醇、血清TGR、HDL、LDL和VLDL有直接相关性。结果显示，服用高血糖药物的患者的TGR水平升高。此外，血清TGR水平与血糖水平显著相关(p = 0.035)。血尿素水平与糖化血红蛋白显著相关(p = 0.008)。血尿素、血清肌酐和血清胆固醇水平与HbA1c呈极显著相关(p分别为0.008、0.017和0.005)，而HDL、LDL和VLDL与HbA1c无显著相关。结论:本研究强调了血清TGR和血清肌酐测定对指导T2DM治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Diabetes and Metabolism

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