POTENSI ANTIINFLAMASI EKSTRAK DAUN KECAPI SENTUL (Sandoricum koetjape Merr) DENGAN METODE STABILISASI MEMBRAN SEL DARAH MERAH

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pub Date : 2023-03-31 DOI:10.36387/jiis.v8i1.1277

Yusrinie Wasiaturrahmah, Nida Amalia

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Abstract

Tissues that experience detrimental disturbances caused by chemical, mechanical or infectious stimuli will respond in the form of inflammation. Inflammatory processes that cannot be controlled and last long can damage cells, causing pathological effects. Kecapi sentul (Sandoricum koetjape Merr) is a plant that can thrive in Indonesia. Kecapi sentul leaves contain saponins, flavonoids, tannins, alkaloids, steroids, phenolics, and triterpenoids. The content of bioactive compounds in kecapi sentul leaves can provide various pharmacological effects, including as an anti-inflammatory. This study aims to determine the anti-inflammatory potential of kecapi sentul leaf extract using the membrane stabilization of the red blood cell method. The results showed that the percentage value of hemolysis inhibition possessed by kecapi sentul leaf extract at concentrations of 50, 100, 200, and 400 ppm were 6.137%, 15.884%, 24.549%, and 40.433%. The percentage of hemolysis inhibition possessed by 100 ppm aspirin as a positive control was 60.650%. The IC50 value of Kecapi sentul leaf extract was 492.305 ppm. Kecapi Sentul leaf extract is known to have the potential as an anti-inflammatory.

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琵琶提取物(Sandoricum koetjape Merr)的潜在反炎症提取方法稳定红细胞的细胞膜

受到化学、机械或感染性刺激的有害干扰的组织将以炎症的形式作出反应。炎症过程无法控制且持续时间长，可损伤细胞，引起病理作用。山皮(Sandoricum koetjape Merr)是一种可以在印度尼西亚茁壮成长的植物。槲皮叶中含有皂苷、黄酮类化合物、单宁、生物碱、类固醇、酚类物质和三萜。槲皮叶中所含的生物活性物质具有多种药理作用，包括抗炎作用。本研究旨在利用红细胞膜稳定法测定槲皮叶提取物的抗炎潜能。结果表明，在50、100、200和400 ppm浓度下，虎皮叶提取物的溶血抑制率分别为6.137%、15.884%、24.549%和40.433%。以100ppm阿司匹林为阳性对照，溶血抑制率为60.65%。槲皮叶提取物的IC50值为492.305 ppm。众所周知，山葵叶提取物具有抗炎的潜力。

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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

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