Intubation Biomarkers in COVID Critical Care Patients

Abstract

Objective: The coronavirus disease-2019 (COVID-19) pandemic is an important cause of mortality worldwide and has created a serious burden for intensive care units (ICU). Many biomarkers have been studied in terms of mortality and are used routinely. This study aims to look at the laboratory data of patients transferred to the intensive care as well as the laboratory data on the day of intubation to try to figure out which biomarkers can help predict the intubation procedure. Material and Methods: Patients in the COVID ICU had their records retrospectively reviewed. The study comprised patients who received oxygen therapy at the time of admission and had a positive polymerase chain reaction (PCR) test in the ICU, as well as patients who were endotracheal intubation after 24 h due to respiratory distress and/or other complications. Patients’ information was gleaned from the hospital’s computer database and patient files. The data of patients hospitalized in the COVID ICU were reviewed retrospectively. Patients who received oxygen therapythe firstirst admission with PCR test positive at ICU and patients who were intubated after 24 h due to respiratory distress and/or other accompanying reasons were included in the study. The data of the patients were obtained from the hospital computer database and patient files. Results: Lactate dehydrogenase, fibrinogen, ferritin, D-dimer, international normalized ratio (INR), WBC, neutrophil, neutrophil lymphocyte ratio (NLR), I-granulocyte, Sequential Organ Failure Assessment score (p<0.001) and pro-C, urea, INR, hemoglobin, lymphocyte scores were compared when the patients were intubated upon admission. There was a statistically significant difference in the values (p<0.05). Conclusion: Acute phase reactants (AFR) increase in COVID-19 pneumonia. In the follow-up of the disease, it can be used in I-granulocytes with NLR as well as the increase in AFR. In this study, in addition to the increase in acute phase reactants compared to the laboratory data of intubated patients admitted to the intensive care unit, we found higher I-granulocyte and neutrophil lymphocyte ratio ratios.