The development of graphene coated measuring plate for the investigation of “dark” neurons with electrical impedance spectrum (EIS) measurement

2021 IEEE 15th International Symposium on Applied Computational Intelligence and Informatics (SACI) Pub Date : 2021-05-19 DOI:10.1109/SACI51354.2021.9465541

Kiara Berta, Reka Varga, Nina Gyorfi, Kristof Tenzlinger, Á. Odry, P. Odry, A. Széchenyi, Z. Karádi, Attila Tóth, Zoltán Vízvári, Jozsef Pal

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Abstract

Compacted neurons are morphologically changed axons in an undamaged environment, which are able to recover spontaneously. They may play an important role in neurological disorders, such as Parkinson’s disease or Alzheimer’s disease. The aim of this study was to find the best method for the investigation of this process. Therefore we designed and selfmade bio-impedance spectrum (BIS) measurement plates with three different electrode distances (1mm, 3mm, 5mm). Due to measurements using self-developed software, we got the result that plates with 3mm and 5mm distance setups are suitable for our future research studies. The validation measurement was carried out with series of solutions made of ion exchanged water and physiological saline solution (concentrations: 0%, 25%, 50%, 75%, and 100%) Due to successful plate development, it became possible to continuously measure the process of compaction and recovery of the dark neurons, and find out the details of this phenomenon.

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应用电阻抗谱(EIS)测量研究“暗”神经元的石墨烯涂层测量板的研制

紧致神经元是在未损伤环境下形态改变的轴突，能够自发恢复。它们可能在帕金森病或阿尔茨海默病等神经系统疾病中发挥重要作用。本研究的目的是寻找研究这一过程的最佳方法。为此，我们设计并自制了三种不同电极距离(1mm、3mm、5mm)的生物阻抗谱(BIS)测量板。由于使用自行开发的软件进行测量，我们得到的结果是3mm和5mm距离设置的板适合我们未来的研究。验证测量采用离子交换水和生理盐水溶液(浓度:0%、25%、50%、75%、100%)组成的一系列溶液进行，由于板显影成功，可以连续测量暗神经元的压实和恢复过程，并找出这一现象的细节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2021 IEEE 15th International Symposium on Applied Computational Intelligence and Informatics (SACI)

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