Presente y futuras perspectivas en el abordaje farmacológico del dolor neuropático

Abstract

Introduction: Neuropathic pain (DN) is difficult to treat due to the heterogeneity of underlying causes, symptoms, and mechanisms. It constitutes a great unmet medical need, and has a high number of therapeutic failures in recent randomized clinical trials. Development: This narrative review presents an update on the pharmacological treatment of NP with emphasis on the new published clinical guidelines, new drugs in development, and the future perspectives that arise in the therapeutic management of this entity. Conclusions: Although the first-line drugs in the treatment of NP include, among others, anticonvulsants, the latest studies question the role of pregabalin, which leads us to consider periodic updates of the guidelines necessary for better clinical practice.